Lt-Col Priscilla Naidu said the 54-year old man was arrested in his home after two mothers opened cases of sexual assault in August.
The sexual offences apparently took place in 2003 in the doctor’s consulting room.
Three of them were siblings, aged between eight and 10 at the time.
The fourth child was assaulted when he was nine-years-old.
The doctor was released on bail after appearing in the Humansdorp Magistrate’s court.