The top two sides in the South African Conference clash in Durban on Saturday evening; the only local derby scheduled for the fourth round of Vodacom Super Rugby.
The Sharks, who are unbeaten after two matches and top the SA log on nine points, host the Lions, who won two of their first three matches and are one point behind the KwaZulu-Natalians.
In the three other matches involving South African teams, the Cheetahs, Stormers and Bulls all face previous champions.
The Toyota Cheetahs take on the Reds (2011 champions) in Brisbane and the Stormers are away to the most successful side in the history of the competition, the seven-time champion Crusaders in Christchurch.
Back in Pretoria, the Bulls host the Blues (champions in 1996, 1997 and 2003) at Loftus Versfeld, where their stalwart-wing Akona Ndungane will join his twin brother, Odwa, and 21 other South Africans on a special list when he plays in his 100th Vodacom Super Rugby match this weekend.
They are the second set of brothers to achieve this feat, following in the footsteps of Odwa’s team-mates at the Sharks, Jannie and Bismarck du Plessis.
The full list of South African Vodacom Super Rugby centurions:
127: Victor Matfield (Cats 8, Bulls 119)
125: AJ Venter (Cats 19, Sharks 96, Stormers 10) and John Smit (Sharks)
123: Morné Steyn (Bulls)
122: Stefan Terblanche (Sharks)
118: Bryan Habana (Bulls 61, Stormers 57)
116: Danie Rossouw (Bulls), Jannie du Plessis (Cheetahs 26, Sharks 90)
114: Jacques Botes (Sharks)
113: Pedrie Wannenburg (Bulls), Adi Jacobs (Bulls 21, Cats 4, Sharks 88)
112: Fourie du Preez (Bulls)
110: Wynand Olivier (Bulls)
108: Ollie le Roux (Natal 24, Sharks 60, Cats 3, Cheetahs 21), Meyer Bosman (Cheetahs 61, Sharks 47)
107: Odwa Ndungane (Bulls 10, Sharks 97)
105: Bismarck du Plessis (Sharks)
104: Andries Bekker (Stormers), Jano Vermaak (Cats 11, Lions 62, Bulls 31)
103: Pierre Spies (Bulls)
102: Albert van den Berg (Cats 7, Sharks 95)
100: Bakkies Botha (Bulls)